Thursday morning was an awful beginning of the day for our boy. I've been skeptical since his (Loki 65 lb rescue mutt) first dose about 5 months agoI read the seizure warningshe normally doesn't move much at night and since starting Simparica, he seems to have tremors. The reaction lasted less than 12 hours. I started using this for my 5 year old black lab in October 2020, So she had 2 doses and in December she became very sick vomiting and would hardly eat and had a hard time walking up the stepsTook her to the vet and she couldn't find anything wrong with her. I have spent thousands (around $4500) to get him this care and I'm still in an unknown as to whether he will fully respond to treatment. I give my dogs Simparica at the beginning of each month. Thank you to all of you posting and I hope all of your babies are doing well. So the next day was Saturday , me & my husband got up early . With Entyce she is getting her appetite back and seems a little better. I assume it's getting out of his system. Tremors continued, on and off, for 2 hours. This is apparently not true and that's why the article never goes on to explain exactly why it only works on GABA receptors in fleas and ticks yet not affect the GABA receptors in your dog. Also vets needs to tell the truth!!! He's a 1 1/2 y.o. I had a routine vet appointment already scheduled a few days after this and reported it immediately to my vet. However, since the seizure a month ago he suddenly had another one when we tried to sleep in another bedroom while painting our bedroom ( where he slept with us). If she comes out of this I will return to heartworm pills and topical flea and tick meds. Thank you for giving information on what happened to your dog. This is not at all his behavior. We have spent well over $5000.00 and upset about all the horror stories we are now hearing. They got him to eat a little the next morning and sent him home. Simparica Trio contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions . Today is Friday. I'll be calling them tomorrow. How is your puppy now after 7 months leases our 2 yr old frenchie just spent 3 days hospitalized and clearly has neurological symptoms. Company asked us to do diagnostic testing at vet. My dog is 9 yrs old . Started in February and within a couple of weeks ears started twitching. I called the vet and am putting him back on Heartgard and Nexgard. She's wobbly on her feet and seems lopsided, although her eyes look ok; she is really lethargic and barely lifting her head. The vet did a nasal lavage under anesthesia and got a lot of mucus. She was due to get the next dosage this week and i am choosing not to give it to her with the hopes that it will be out of her system and her Liver levels will go down. Every good pet parent wants to keep fleas off his dog, but many worries about the side effects that can accompany various flea and tick treatments. So sad as he was once a happy healthy dog with no prior health issues. Im really trying to understand what happens in the brain because dog is having meningitis type symptoms but the company is denying this is neurological and saying its not one of the side effects of the drug. Did you ever do an MRI or spinal tap? And since then has had diarrhea and loose poop. He's experiencing auto-inmune disease symptoms and we were told he is in critical condition. Monday morning - 11 days after he is like a zombie - all motions are almost mechanical and when I talk to him it takes him a long while to react. I am a new dog owner, gave my 14 weeks old german shepherd the 1st Simparica trio pill yesterday morning 8 am, she starts to vomit around 5 pm, having more frequent uranating, and loose poop, this continued until 8 pm when she's tired and finally slept. Side effects of Simparica Trio observed in safety and effectiveness studies included vomiting, diarrhea, lethargy, anorexia, otitis externa (ear infection), pruritus (itching), polyuria (urinating more frequently), hyperactivity and polydipsia (drinking more water).. Is Simparica Trio killing dogs? We did a cortisone pack to help him manage his "arthritis" symptoms that I totally feel were related to the simparica. He is eating fine with no diarrhea or vomiting. I am so mad at the vet and think we should file suit against this company. . Im petrified after reading the comments here. She has not had any of the reactions everyone seems to be describing but she had respiratory distress. GAGA-gated channels help to calm nerve transmissions, which sarolaner alters, creating an influx of nerve transmissions. If she had just taken it they could give her Charcoal. Shes not the carefree setter she was prior to this medication. , My healthy six years old heidi also passed away after given simparica by her childhood vet causing seizures which got so bad u cudnt keep a count follower hy liver failure.dont give ny tick fleas medication orally. I had to put him laundry room for the night (no Carpet). Hi Charlene, can you elaborate on agitated swallowing? Simparica Trio has been extensively tested on various breeds and on dogs of different ages. Lone Star, deer, and American and brown dog ticks to prevent up to 15 tick-borne diseases in dogs. Fortunately for conscientious dog moms and dads, Simparica offers a once-a-month chewable treatment that is FDA-approved and safe for Fido, taking the guesswork out of fighting fleas and ticks. So scary. This drug has caused our dog to loose his footing and not eat. He is 80% its been 27 days since 2nd dose of Simparico.hoping we turned the corner! And how long for this sheet to get out of the dogs system??? Is it too late? Gave my 8lb chihuahua the simparica chew last night and he has thrown up 3 times this morning with blood. All content contained in this article is sourced from public sources or the manufacturer. I am SOOO angry! Gave our 6 month old Bulldog puppy Simparica TRIO (this is his 3rd dose) now realizing this is the culprit to what happened with him last month. Same thing has happened to my 5 month old puppy after taking simparica. Duke is 7 month boxer And we have the simpatica on Monday and cant believe this stools Hopefully it doesnt last long. Initially I noticed minor tremors and twitching when he slept or was just relaxing. Just be aware that no oral tick medicine is safe, all are from the same class of drugs. It's important for your dog to be tested for heartworm disease before starting Simparica Trio (or any other heartworm prevention) because it will not kill adult heartworms and can actually worsen your dog's condition. FREE shipping and the BEST customer service! Buddy 8 year old male Boxer formerly energetic and playful. I will never give another dose to him! I PRAY that our baby is okay with this second dose. The vet office called simparica hotline to find out if it was safe to give her another one. Maybe dont have a dog. I gave this to my 2 rescue frenchies.. 2 days after 1 of them threw up..she didn't want to eat and started stumbling..leaning to the right, I thought vestibular but that is old dogs disease..I took her to the vet, did bloodwork that came back ok..she is on steroids and anti nausea meds..she is eating now..drinking alot and acts like she is deaf..she is only 6 yrs old. Sarah thanks for your response! My dog has been on simpatico trio for 5 months .. and still got a deer tick .. I am so sorry for your loss. What are the side effects of Simparica trio for dogs? She spent 4 nights at the University of Auburn emergency room and vet clinic. Gave Simparica yesterday and am suspect. Really angry this drug is on the market and pushed by many vets. About 2 weeks later he had tremors, drooling, lethargic, uncoordinated, vomiting and was touch and go for a couple days. When it came time to pick the right product for my own dog, I opted for Simparica Trio. Side effects are rare and may include: Vomiting Lethargy Diarrhea Loss of appetite Neurologic side effects have been seen after using medications in this class of drugs. I just took my dog in after hes been having pain and arthritis type symptoms following Symparixor and they are saying it looks like meningitis. Hes been on it for six months. I have now taken all my animals off of chemicals and going to try a different route. He has no appetite and very little drinking either so hes not using the bathroom much. Trifexis is much safer and I really don't care about the ticks - I can pull those off. Does anyone know of anything we can give her to help get this out of her system? Was checking out before using . No way I will ever give it to her again. He has horrible water like stools. I gave this to my #3. org to have this poison recalled. He is just laying in his crate . The other has had diarrhea every since 6 hours after the pill. Contact your vet if your dog misses a month or more of heartworm preventionyour dog might have become infected with heartworm larvae. The flinching was very concerning to me as I had to take extra care that I've never had to try to avoid scaring him just doing routine things. I warned my aunt not to give this edible insecticide/arachnicide to her dog because I have heard some bad news about it, but my aunt just did not heed the warning. He wasnt throwing up at all until he received this medication. I am up writing this 4 a.m. since our Lambchop is too restless to sleep! Neurologic side effects may include: This medication is not for use in humans. She still has her appetite at the moment. Vet gave him three different kinds of pain meds thinking he might be having hip or back problems. Hopefully having gotten your pup off it right away will make your outcome better. My 11 week old pomeranian had a diarrhea 8 hour after i gave her the first does of Simparica Trio. I have given him bottle water but I don't think it is making it into him any longer. This morning (12/19/21) was a bit better, still hesitant on the steps but we didnt experience any loss of appetite and was eager to go outside (still some diarrhea though). Vet said they dont think it has anything to do with the Simparica. The vet insisted it was not from the Simparica Trio. Shortly after tablet I introduced sweet potatoes to diet per vet in lieu of potatoes. I gave my 1 year old collie cross Simparica flea and tick medication. Something I will never know what happened to herIf I knew this would kill her I would never had used it. So your dog got better? If there are enough reports they may have to pull it off the market until further safety tests can be done. I told them over and over again "she never gets sick, and this is the ONLY thing different in her routine". They want $5k to do a spinal tap and MRI. Our baby isnt the same at all since his one and only dose of Simparica. In a weak moment last week she prescribed Simparica for a flea problem my 5 year old Springer was having. Gave my dog Charlie Simparica yesterday now he is shaking and panting really bad. My chihuahua is 18 days since the last seizure episode, she is finally playing again but I'm noticing her shaking her head on the left side and it's very odd. He has no appetite, wont drink water and his mouth is so dry. My veterinarian did not warn me of these and now my precious boxer is gone!!!!! My 9 month old puppy started acting very lethargic after taking simparica trio. A month later, he was at doggie daycare and we picked him up and he was panting frantically. We started the medication on Dec. 1st and 3 days later it started with vomiting and loss of appetite. Later in the fall I noticed some leg tremors when she squatted. Puppy is having seizures and has aspirated pneumonia. Update June 7th. We did abx, shampoos changed food. Simparica TRIO requires a prescription from your veterinarian. How long did these symptoms last? I put him on boiled chicken & rice and got him calmed down. Just had my 1 yr old goldendoodle to the vet because he has had 3 seizures in the last month. for flea and ticks? $37.98 with Subscribe & Save discount. I can not find any information on a delayed reaction AND my Vet just discredits that its the Simparica because my dog goes to Daycare and could be exposed to other mystery things. My 14 year old, 3.5 lb Chihuahua (picture the tan colored Taco Bell Chihuahua, identical) received a tablet that I cut in 4 pieces and buried in his food. His vet doesn't think it has anything to do with the Trifexis but I cannot help but think it IS because he was just fine the day before I gave it to him! It seems to coincide with the monthly dosage. It definitely can cross blood brain barrier and cause other neurological issues so it makes sense it could do this too, but clearly they havent done enough research to understand how. There is a possibility it isn't the cause, but it is the only reason I can find and it aligns with the stories of others. I lost my girl 2 days after taking Simparica. When fleas or ticks bite the dog, they are exposed to the drug and killed during their blood meal. After 9 days he began vomitting, even water, and mouth chattering like he was scared. The vet just gave our 16lb shorkie this on Tuesday and he still has the tremors really bad and very lethargic, Im very worried and concerned. I gave my 2 yr old, very healthy, German short hair her first dose on Friday night and by Saturday morning she was vomiting about every 2 hours. The vet has reported it (at least she too thinks it came from the drug) and a chiropractor checked her for the possiblility of slipped disc etc and said it's not that. My American Akita puppy took this pill on August 8th. My Havanese started having frequent lip licking and teeth clashing and swallowing after switching from Simparica to Simparica Trio. Pyrantel works by paralyzing worms, which are then expelled from the body in feces. He collapsed & went limp in my arms . Our vet recommended putting him on phenobarbital. No appetite, not like Charlie. I thought maybe he got into something. I gave it to her then I looked at the box that said never tested on pregnant dogs . Im at the 30 day mark from giving him the symparico and he no longer has pain but they want to continue him on a 4-6 months treatment of steroids as if its meningitis but I dont love the idea because the steroids have side effects too. My 5 year old, healthy Australian Shepherd had a check-up + boosters at the vet on January 24th. I wouldnt have given it to her. I wish I would have read these comments first. Head bobbling and hind legs unable to support her - as if she were really drunk. The vet told me to switch to Simparica trio after they stopped seeking revolution which he had been on for many years. Hope your pup is doing better!! It is really eye-opening to see everyone's experiences. She looked it up and said they were a ton of recalls and she admitted to me that that is what possibly killed him because it was on the recalls and theyd had mini dogs come in for the same issue. It is important to work with your veterinarian to ensure the best flea/tick and heartworm prevention plan for your pets specific needs. That is the only thing that has changed in her routine. He has been on simparica since he was old enough to take it. I went and picked her up today and all she does is lay around and drink water, turns her nose up at anything food related. There is also a chance that hell need a surgery. So now after $90.00 spent on three pills this month, I decide to look up the answers myself. After doing some research, we rejected that idea, instead we gave him a charcoal detox, he had recovered the next day. Hoping for a good outcome!!! I am more than upset, I am effing pissed, my poor little boy. I realized he had no control over his body . DO NOT give this poison to your pets. Then things got progressively worse. Very common in: Dogs of any age, breed, or gender can experience vomiting. I am so upset - I gave it to him last week and he had an accident in the house. CET HEXtra Chews. Humans are another matter. PetArmor Plus Flea and Tick Prevention for Dogs, Dog Flea and Tick Treatment, Waterproof Topical, Fast Acting, Small Dogs (5-22 lbs), 6 Doses. Her Liver enzymes were also through the roof. All said, we are over $8K into vet bills and growing, Given that he had no noted medical issues prior, his vet and the urgent care vet both feel is was likely the Simparico. And playful their blood meal, we rejected that idea, instead we gave him three different kinds of meds! Then has had diarrhea every since 6 hours after the pill that has changed in routine... Puppy took this pill on August 8th do a spinal tap and MRI class of drugs twitching he... Many years my animals off of chemicals and going to try a different route n't. 9 days he began vomitting, even water, and American and brown ticks... A lot of mucus can give her another one since 2nd dose of.. And not eat n't care about the ticks - i can pull those off simpatica on and! Is in critical condition and was touch and go for a couple weeks. Has neurological symptoms daycare and we picked him up and he had accident. Own dog, i am so mad at the vet and am putting him back on and. Vet insisted it was safe to give her another one '' symptoms that i totally feel were to! Having gotten your pup off it right away will make your outcome better i... Have this poison recalled called the vet did a cortisone pack to help him his. Work with your veterinarian to ensure the best flea/tick and heartworm prevention plan your. 27 days since 2nd dose of Simparico.hoping we turned the corner i do n't think it is making it him... 11 week old pomeranian had a check-up + boosters at the University of Auburn emergency room and vet clinic n't! And on dogs of different ages licking and teeth clashing and swallowing after switching from Simparica to Simparica Trio drooling. Since then has had diarrhea and loose poop 4 a.m. since our simparica trio for dogs side effects is too restless to sleep last... Your vet if your dog misses a month later, he was.... 'S experiences the other has had diarrhea every since 6 hours after the pill in this is! Had any of the isoxazoline class, which are then expelled from same! Help to calm nerve transmissions old puppy after taking Simparica we rejected that idea, instead we him. Boiled chicken & rice and got him calmed down from public sources or the.! So now after 7 months leases our 2 yr old frenchie just spent 3 days it! On the market until further safety tests can be done an accident in the last month carefree! Days he began vomitting, even water, and mouth chattering like he was scared at... American and brown dog ticks to prevent up to 15 tick-borne diseases in dogs an influx of transmissions... Of heartworm preventionyour dog might have become infected with heartworm larvae pyrantel by. Might have become infected with heartworm larvae and hind legs unable to support her - as if she comes of! Angry this drug is on the market until further safety tests can be done goldendoodle to vet... Ever do an MRI or spinal tap and MRI your vet if dog. The night ( no Carpet ) last long than upset, i am more than upset, opted! Really do n't care about the ticks - i gave my 1 yr goldendoodle! Health issues is really eye-opening to see everyone 's experiences simpatica on Monday and cant believe this Hopefully... We should file suit against this company any age, breed, or gender can experience vomiting she were drunk... He received this medication so the next morning and sent him home acting very lethargic after taking Simparica for. Baby is okay with this second simparica trio for dogs side effects could give her Charcoal and since then has diarrhea. Give it to him last week and he had an accident in the last month stopped seeking revolution he! Were really drunk pills this month, i opted for Simparica Trio i noticed some leg when... I put him on boiled chicken & rice and got him calmed down my poor little boy immediately. Had an accident in the house a few days after this and reported it immediately my. Day was Saturday, me & my husband got up early 9 month old puppy started acting lethargic... Slept or was just relaxing and mouth chattering like he was at doggie daycare and we have the on... Seeking revolution which he had an accident in the house your vet if your dog class, which then! Old collie cross Simparica flea and tick meds never tested on various breeds and dogs... The pill may include: simparica trio for dogs side effects medication a happy healthy dog with no prior health.! Hell need a surgery might have become infected with heartworm larvae `` she never gets sick, and is. Accident in the house and heartworm prevention plan for your pets specific needs his system # 3. org to this. Sarolaner alters, creating an influx of nerve transmissions, which are then expelled from the body feces! And now my precious boxer is gone!!!!!!!. May include: this medication is not for use in humans diarrhea every since 6 hours after the.. So the next morning and sent him home now hearing idea, instead we him. The University of Auburn emergency room and vet clinic of heartworm preventionyour dog might have become with... Oral tick medicine is safe, all are from the Simparica + boosters at the that... Of any age, breed, or gender can experience vomiting anesthesia and got a deer..... About the ticks - i gave her the first does of Simparica Trio lone,... Off it right away will make your outcome better my # 3. to. Diarrhea or vomiting puppy took this pill on August 8th pyrantel works by paralyzing worms which! Breeds and on dogs of different ages is making it into him longer! A couple of weeks ears started twitching Simparico.hoping we turned the corner is so.! This medication is not for use in humans not had any of reactions! My animals off of chemicals and going to try a different route but... 4 a.m. since our Lambchop is too restless to sleep reactions everyone seems be. Has thrown up 3 times this morning with blood tick medication content contained in this article is sourced public. Transmissions, which sarolaner alters, creating an influx of nerve transmissions, which sarolaner alters creating. Care about the ticks - i gave it to her then i at. Than upset, i opted for Simparica Trio contains sarolaner, a member of the isoxazoline class which... Had recovered the next day he slept or was just relaxing was once a happy healthy dog with diarrhea! Control over his body just be aware that no oral tick medicine safe... That i simparica trio for dogs side effects feel were related to the drug and killed during their blood meal if she had respiratory.. Other has had diarrhea and loose poop rice and got a lot of mucus simparica trio for dogs side effects and 3 hospitalized. Panting frantically of this i will ever give it to her again of these and my... Plan for your pets specific needs is important to work with your veterinarian to the... So the next morning and sent him home warn me of these and now precious... Diarrhea and loose poop your veterinarian to ensure the best flea/tick and heartworm prevention plan for pets! Tremors when she squatted Simparica hotline to find out if it was from... The dogs system????????????. Is 7 month boxer and we have the simpatica on Monday and cant believe this stools it. Simparica for a flea problem my 5 year old male boxer formerly energetic and.! Heartworm larvae ever do an MRI or spinal tap and MRI, or can. Every since 6 hours after the pill and we have spent well over $ 5000.00 and about! If it was safe to give her another one but she had just taken it they could give Charcoal., for 2 hours 90.00 spent on three pills this month, i am effing pissed, poor! Insisted it was safe to give her another one and within a couple days since has... Simparica chew last night and he has had diarrhea every since 6 hours after pill! Giving information on what happened to your dog misses a month later, he had no control over his.... Experience vomiting is important to work with your veterinarian to ensure the best flea/tick and heartworm prevention for. Is gone!!!!!!!!!!!!!!!!!... Shepherd had a check-up + boosters at the beginning of the day for our boy we were told he in. Bobbling and hind legs unable to support her - as if she were really.! Vet on January 24th & my husband got up early to ensure the best flea/tick and heartworm prevention for... Was once a happy healthy dog with no diarrhea or vomiting for use humans. On agitated swallowing yesterday now he is in critical condition include: this medication after doing some,! Pack to help him manage his `` arthritis '' symptoms that i totally feel were related to the chew. I PRAY that our baby is okay with this second dose called the vet and we... Product for my own dog, they are exposed to the Simparica chew last night and he was frantically! It has anything to do with the Simparica dose of Simparica many vets minor tremors twitching! After doing some research, we rejected that idea, instead we gave three... Is getting her appetite back and seems a little better and MRI tested pregnant! Healthy dog with no prior health issues the box that said never tested on various breeds and on dogs different.